Description
Discussion
Relora Calm Plus is a multifunctional herbal supplement that has far-reaching and complementary benefits for individuals seeking help in dealing with everyday stress. It features a unique combination of clinically tested and patented ingredients, including Relora®, Sensoril®, and Suntheanine®, along with Siberian Ginseng and Rhodiola. Together, these herbs help the overstressed body and mind work toward their normal state of balance and resolve many of the biochemical changes that occur as a result of repeated, frequent exposure to stressors and cortisol.*
Relora® is a patented and proprietary blend of Magnolia officinalis and Phellodendron amurense bark extracts standardized to honokiol and berberine, respectively. These herbs have a history of traditional use in treating stress and occasional feelings of anxiousness. In modern times, they and their actives (honokiol and berberine) are used to support relaxation and reduce the perception of stress and stress-related eating. Rodent stress studies demonstrate a reduction in induced feelings of anxiousness.[1,2] Human studies demonstrate positive changes in DHEA (dehydroepiandrosterone) and cortisol levels, less weight gain (compared to controls), and reductions in perceived stress and transitory feelings of anxiousness in subjects taking Relora (500 mg to 750 mg for four to six weeks).[2-5] As an example, cortisol exposure and psychological mood states were studied in 56 subjects (35 men and 21 women) taking Relora (250 mg twice daily) or placebo. After four weeks of supplementation, salivary cortisol exposure was significantly (p<0.05) lower (−18%) in the Relora group compared to placebo. The Relora group also had significantly better (p<0.05) mood state parameters, including lower indices of overall stress (−11%), tension (−13%), anger (−42%), occasional fatigue (−31%), and confusion (−27%), and higher indices of global mood state (+11%) and vigor (+18%).*[3]
Sensoril® is an optimized ashwagandha (Withania somnifera) root and leaf extract that represents a major advancement in ashwagandha preparations. Sensoril’s proprietary and patented extraction process produces very high, powerful levels of stress-fighting, cognition-enhancing ashwagandha bioactive constituents. In fact, Sensoril is standardized to a minimum of 10% glycowithanolides. Sensoril’s excellent safety record is one of the most comprehensive of any ashwagandha ingredient sold.* Ashwagandha has been revered as an adaptogen for thousands of years. It is used to balance, energize, and revitalize the body and for its value as a cognition enhancer. Sensoril possesses multiple health benefits, and its superior efficacy has been demonstrated in randomized, double-blind, placebo-controlled human clinical trials.[6-10] The results of these trials revealed that Sensoril, taken in doses of 500 to 1000 mg/d, supported healthy cortisol and DHEA levels; enhanced working memory, reaction time, and cognitive capacity; improved auditory-verbal working memory; ameliorated negative changes in cardiovascular parameters associated with mental stress; and improved endothelial function and glucose and lipid metabolism.*
Suntheanine® is a pure form of L-theanine that is produced via a patented fermentation process, resulting in a 100% pure L-isomertheanine. Clinical research suggests that 50 to 200 mg/d of Suntheanine naturally stimulates activity in the brain known as alpha waves, which are associated with a relaxed but alert mental state.[11] L-theanine had significant anti-stress effects on experimental animals under psychosocial stress.[12] In humans, similar results were observed wherein L-theanine helped the body resist biochemical changes associated with stress.[13,14]
In a randomized, double-blind, placebo controlled trial, a high dose of Suntheanine (400 mg/d) given to boys, aged 8-12 years, improved aspects of sleep quality, including significantly higher sleep percentage and sleep efficiency scores as well as a non-significant
trend for less activity during sleep.*[15]
Eleutherococcus senticosus (Siberian ginseng – Root) Eleutherococcus senticosus, commonly known as Siberian ginseng, has been traditionally valued for its numerous health benefits. The root of this adaptogenic herb is rich in bioactive compounds that are believed to enhance the body’s resilience to stress, both physical and mental. Siberian ginseng is renowned for its ability to boost energy levels, reduce fatigue, and improve overall stamina. It is often used to support the immune system, promoting a robust defense against infections and illnesses. Additionally, Siberian ginseng is recognized for its potential to enhance cognitive function, including improved concentration and mental clarity. As an adaptogen, it helps the body adapt to various stressors, contributing to a sense of balance and well-being. Whether incorporated into dietary supplements or herbal formulations, Siberian ginseng continues to be a popular choice for those seeking natural support for vitality and stress resilience.
Rhodiola rosea (rhodiola) This adaptogenic herb has been used traditionally in Eastern Europe and Asia for centuries to increase stamina, maintain a healthy mood, support the nervous and immune systems, and maintain healthy male sexual function.[8,9] According to Panossian et al, experimental studies performed on isolated organs, tissues, cells, and enzymes demonstrate that rhodiola preparations exhibit adaptogenic effects that support nerve, brain, and heart health and are calming, longevity-enhancing, and central nervous system- stimulating.[9] In addition, experimental animal models suggest that the root extract may be able to support normal heart rhythm.[10] Rhodiola may also have a positive effect on brain neurotransmitters, such as dopamine and serotonin, and may influence endogenous opioid levels. [8] According to a review of the literature on rhodiola, supplementation supports healthy work performance, quality of sleep, appetite, and energy levels subsequent to intense physical or intellectual strain. Salidrosides and rosavin have been identified as primary actives. The rhodiola extract in this formula is standardized to provide no less than 1%-3% salidrosides and 3% rosavin.*
Relora Calm Plus with SENSORIL®
Medicinal Ingredients (per capsule):
Withania somnifera (Ashwagandha – Root, Leaf) . . . . . . . . . . . . . . . . . . . . . . . . 125 mg
(0.5% Withaferin A, 0.05% Withaferin A, 20% Withanolide glycosides, 10% Withanolide glycosides, 45% Withania oligosaccharides, 32% Withania oligosaccharides)
L-Theanine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 mg
Eleutherococcus senticosus (Siberian ginseng – Root). . . . . . . . 75 mg (15:1, 1125 mg)
Rhodiola rosea (Root) . . . . . . . . . . . . . . . . . . . . 37.5 mg (1% Salidroside, 3% Rosavins)
Magnolia officinalis (Magnolia Bark – Stem bark) . . . . . . . . 34.38 mg (8.5% Honokiol)
Phellodendron amurense (Aged bark). . . . . . . . . . . . . . . . . . 11.25 mg (2.5% Berberine)
Non-medicinal ingredients: Microcrystalline cellulose, Magnesium stearate, Hypromellose, Pregelatinized starch, Corn Starch, Silica, Maltodextrin, Lavender Flower Extract
SENSORIL® is protected under U.S. Patent No. 7,318,938 and CA Patent No. 2,508,478, and is a registered trademark of Natreon, Inc.
Directions of use: Adults: Take 1 capsule twice a day. Avoid taking before bedtime. Duration of use: Consult a health care practitioner for use beyond 1 month.
Warnings:
| Consumption with alcohol, other medications or natural health products with sedative and/or analgesic properties is not recommended. |
| Consult a health care practitioner if you are taking any prescription medication, if you have a kidney disorder, or if you have blood pressure problems. |
| Consult a health care practitioner if you have any type of acute infection. |
| Concomitant use with herbs, supplements and medications that have sedative properties might increase the risk of excessive drowsiness. |
| Consult a health care practitioner prior to use if you suffer from any psychological disorder and/or condition such as frequent anxiety or depression. |
| Consult a health care practitioner if symptoms persist or worsen. |
| Consult a health care practitioner prior to use if you are taking antidepressant medication, or hormone replacement therapy. |
Contra-indications:
| Do not use if you are pregnant or breastfeeding. |
| Do not use this product if you have high blood pressure. |
| Do not use this product if you have bipolar disorder or bipolar spectrum disorder. |
Known Adverse Reactions
| May cause heartburn, shaking hands, perilabial numbness, sexual dysfunction and thyroid dysfunction. |
| Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. |
References:
1. Sufka KJ, Roach JT, Chambliss WG Jr, et al. Anxiolytic properties of botanical extracts in the chick social separation-stress procedure. Psychopharmacology (Berl). 2001 Jan 1;153(2):219-24. [PMID: 11205422]
2. LaValle JB, Hawkins EB. Botanicals in dietary supplements: Stress and anxiety: the potential benefit of a proprietary combination of magnolia and phellodendron extracts. Dana Point, CA: Integrative Health Resources; 2013:1-15. http://www.nextpharmaceuticals.com/stage/pdfs/Relora%20Article-2013-LaValle.pdf. Accessed February 22, 2015.
3. Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 Aug 7;10(1):37. [PMID: 23924268]
4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med. 2006 Jan-Feb;12(1):50-54. [PMID: 16454147]
5. Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2008 Apr 21;7:11. [PMID: 18426577]
8.Chan SW. Panax ginseng Rhodiola rosea and Schisandra chinensis. Int J Food Sci Nutr. 2012 Mar;63 Suppl 1:75-81. [PMID: 22039930]
9.Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010
Jun;17(7):481-93. [PMID: 20378318]
10.Maslov LN, Lishmanov IuB. [Cardioprotective and antiarrhythmic properties of Rhodiolae roseae preparations] [in Russian]. Eksp Klin Farmakol. 2007 Sep-
Oct;70(5):59-67. [PMID: 18074810]
11. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. [PMID: 18296328]
12. Tian X, Sun L, Gou L, et al. Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain Res. 2013 Mar 29;1503:2432.
[PMID: 23395732]
13. Unno K, Tanida N, Ishii N, et al. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav. 2013 Oct;111:128-35. [PMID: 24051231]
14. Yoto A, Motoki M, Murao S, et al. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012 Oct 29;31:28. [PMID: 23107346]
15. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011 Dec;16(4):348-54. [PMID: 22214254]
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